No-Significant-Risk-Level (NSRL) values have historically been derived by the State of California based on a prescribed set of calculations that rely on cancer response data and on an assumption of a low-dose linear dose-response relationship, despite the law allowing for flexibility in approaches. This poses a challenge for chemicals whose mode of action is inconsistent with this assumption.
SciPinion assembled a panel of experts to derive NSRL values for three acrylates (methyl, ethyl, 2-ethylhexyl) using best available science. Based on this panel’s input for key decisions in the assessment, the resulting NSRL values were derived based on nonneoplastic, cancer-precursor lesions reported at the point of contact using a nonlinear method (uncertainty factor approach) for low-dose extrapolation. SciPinion’s approach for this effort is the first of it’s kind to assure that a risk value (in this case a NSRL) is based on best available science and the collective wisdom of the world’s experts.
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POD values for MA, EA, and 2EHA. X’s = BMD10, bars = BMDL10, BMDU10; hollow circles = NOAEL; solid circles = LOAEL; dashed lines = uncertainty factor application; diamonds = value used to calculate NSRL.