SciPinion conducted an expert elicitation to characterize the state of the literature on this topic, evaluate the interconnections amongst risk factors, and identify those that are a priority for future research. A panel of 30 scientists and physicians with expertise in birth outcome epidemiology were solicited to identify a series of health outcomes and associated risk factors.
SciPinion has published an experts panel’s findings in Regulatory Toxicology and Pharmacology clarifying how 1,4-dioxane produces tumors in laboratory animals. Six experts in toxicology and cancer risk assessment identified metabolic saturation as an early key event, with strong support for non-genotoxic modes of action over direct DNA damage. These findings support the use of non-linear extrapolation methods in human health risk assessment.
A SciPinion panel identified substantial methodological flaws with a publication that proposed that water-soluble film composed of polyvinyl alcohol (PVA or PVOH) used in unit-dose laundry products (laundry pods or capsules) is not completely degraded in wastewater treatment plants.
1,3-Butadiene (BD) is an important industrial chemical used as a building block precursor for synthetic rubber materials including tires, hoses, gaskets, and other polymer products. While BD serves critical industrial functions, questions have persisted about potential human health risks from environmental and occupational exposures, particularly regarding cancer and noncancer effects.
SciPinion conducted an independent review of a publication proposing that water-soluble film composed of polyvinyl alcohol (PVA or PVOH) used in unit-dose laundry products (laundry pods or capsules) is not completely degraded in wastewater treatment plants.The expert panel identified substantial methodological flaws in the original publication.
A SciPinion and Waterborne Environmental collaboration with CDC brings important research that shines a light on metal nanoparticle modeling that will ultimately enhance occupational health protections for those working with nanoparticles.
A SciPinion panel created process for determining the breadth and depth of peer review of exposure models was developed with input from a panel of exposure-modeling experts. This included consideration of the tiers and types of models (e.g., screening, deterministic, probabilistic, etc.).
Work from a recent SciPinion panel was recently published in a manuscript entitled “Derivation of no significant risk levels for three lower acrylates: Conclusions and recommendations from an expert panel”. Novel to this approach were: (1) derivation of a panel-driven NSRL value; (2) use of nonneoplastic tumor precursor data; and (3) nonlinear extrapolation to low doses (uncertainty factor approach) based upon mode of action considerations.
An international panel of experts reviewed the cancer weight of evidence (WOE) and mode of action (MOA) information for three lower acrylates (methyl, ethyl, and 2-ethylhexyl), coming to a contrary finding to IARC’s recent conclusion.
Immunotoxicity is the critical endpoint used by some regulatory agencies to establish toxicity values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). However, the hypothesis that exposure to certain per- and polyfluoroalkyl substances (PFAS) causes immune dysregulation is subject to much debate. An independent, international expert panel was engaged utilizing methods to reduce bias and “groupthink”.
A pesticide (1,3-Dichloropropene – 1,3-D) had been historically classified as a likely human carcinogen. The registrant, through a series of studies, had determined that the carcinogenic potential of the formulation was due to the carrier and not the active agent. SciPinion assembled a panel of experts in toxicokinetics, genotoxicity, cancer bioassays and cancer weight of evidence to review the literature and weigh in on how 1,3-D should be classified. The panel of experts were in agreement that 1,3-D should be classified as ‘Not Likely to be Carcinogenic to Humans’. US EPA agreed with this assessment and changed their classification of 1,3-D.
A new peer-reviewed report by a panel of scientists sheds new light on regulation and management of per- and polyfluoroalkyl substances (PFAS). SciPinion, which objectively engages the global scientific community to analyze the toughest scientific topics, today announced the publication of an important academic report on PFAS, a class of chemicals that have a myriad of commercial uses.
A leading consumer products company needed to know if they were doing everything they could to prevent product contamination and assure product safety. SciPinion assembled a panel of experts and former directors of product safety from companies in the same sector to provide input on best practices. The results provide an exhaustive summary of Best Practices of product safety and monitoring for the consumer product industry.
A Fortune 100 consumer products company used SciPinion to engage over 60 experts from all over the world to peer review their vast pre-clinical and clinical portfolio. The reports from the peer reviews were submitted to FDA. The FDA decided in favor of the client and granted registration for the product, the first ever such registration for a product of that type.
A fortune 100 company needed independent insights on sunscreen formulation, specifically on how to best achieve SPF targets without use of an ingredient that was in the process of being banned. SciPinion was able to engage more than a dozen experts in sunscreen chemistry/formulation to give the company valuable insights on ingredient replacements that would still achieve their target SPF requirements.