A SciPinion and Waterborne Environmental collaboration with CDC brings important research that shines a light on metal nanoparticle modeling that will ultimately enhance occupational health protections for those working with nanoparticles. The collaborative effort advances the state-of-the-science for physiologically based pharmacokinetic (PBPK) modeling of metal nanoparticles, critically evaluating existing models and identifying data needs to enhance human health risk assessment, ultimately supporting improved worker safety protocols for occupational inhalation exposures.
A panel of nine, which brought together international experts, focused on evaluating physiologically based pharmacokinetic (PBPK) models for metal nanoparticles. These models are crucial for assessing human health risks in occupational settings where nanoparticle exposure is a concern. The panel’s s findings have been recently published as a peer reviewed manuscript in the latest volume of the journal Nanotoxicology.
- A comprehensive review of four model groups, scored using guidelines from the Organisation for Economic Cooperation and Development (OECD).
- Successful prediction of nanoparticle behavior in rat lungs, providing valuable insights for human health risk assessment.
- Identification of critical data needs for advancing the field, including improved particle characterization and long-term exposure data.
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Figure 1. Human model predictions: (A) lung burden; (B) Liver burden; (C) Kidney burden; (D) Internal dose ratios (predicted tissue concentration in humans:predicted tissue concentration in rats).