SciPinion Center for Chemical Risk Assessment and Classification
Establishing scientific consensus on chemical safety through rigorous, independent expert review. The Center convenes international panels of toxicologists, epidemiologists, and risk assessment specialists to evaluate evidence on chemical classification, safe exposure limits, and potential health effects.
Discuss Your Chemical Safety Challenges
Expert panels evaluate chemical safety evidence using methodologies aligned with OECD, IARC, and EPA frameworks through our certified SciPi peer review process.
Chemical Risk Assessments
Hazard & Exposure Analysis
Proposed Modes of Action
Mechanistic Pathways
Repro/Developmental Classifications
Reproductive Toxicology
Cancer Classifications
Carcinogenicity Assessment
Independent Expert Panels · Objectivity by Design
SciPinion Panel Findings
Independent expert panels delivering objective scientific reviews on chemical hazard classification, risk assessment methodologies, and safe exposure determinations.
SciPinion Expert Panel Validates Current 1,3-Butadiene Risk Assessment Approaches
1,3-Butadiene (BD) is an important industrial chemical used as a building block precursor for synthetic rubber materials including tires, hoses, gaskets, and other polymer products. While BD serves critical industrial functions, questions have persisted about potential human health risks from environmental and occupational exposures, particularly regarding cancer and noncancer effects. Read more here.
Cancer Classification – Pesticide
A pesticide (1,3-Dichloropropene – 1,3-D) had been historically classified as a likely human carcinogen. The registrant, through a series of studies, had determined that the carcinogenic potential of the formulation was due to the carrier and not the active agent. SciPinion assembled a panel of experts in toxicokinetics, genotoxicity, cancer bioassays and cancer weight of evidence to review the literature and weigh in on how 1,3-D should be classified. The panel of experts were in agreement that 1,3-D should be classified as ‘Not Likely to be Carcinogenic to Humans’. US EPA agreed with this assessment and changed their classification of 1,3-D. Read more here.
SciPinion Panel Derived No-Significant-Risk Levels (NSRLs)
Work from a recent SciPinion panel was recently published in a manuscript entitled “Derivation of no significant risk levels for three lower acrylates: Conclusions and recommendations from an expert panel”. Novel to this approach were: (1) derivation of a panel-driven NSRL value; (2) use of nonneoplastic tumor precursor data; and (3) nonlinear extrapolation to low doses (uncertainty factor approach) based upon mode of action considerations. Read more here.