SciPinion Center for Chemical Risk Assessment and Classification
Establishing scientific consensus on chemical safety through rigorous, independent expert review. The Center convenes international panels of toxicologists, epidemiologists, and risk assessment specialists to evaluate evidence on chemical classification, safe exposure limits, and potential health effects.
Discuss Your Chemical Safety ChallengesExpert panels evaluate chemical safety evidence using methodologies aligned with OECD, IARC, and EPA frameworks through our certified SciPi peer review process.
Chemical Risk Assessments
Deriving toxicity values (reference values, cancer potency estimates, occupational exposure limits), peer reviewing, and certifying best available science based risk assessments
Proposed Modes of Action
Peer reviewing & certifying weight of evidence for evaluation of proposed modes of action
Repro/Developmental Classifications
Peer review & certifying chemical weight of evidence to support Repro/Dev classification decisions
Cancer Classifications
Peer review & certifying chemical weight of evidence to support cancer classification decisions
SciPinion Panel Findings
Independent expert panels delivering objective scientific reviews on chemical hazard classification, risk assessment methodologies, and safe exposure determinations.
Risk Assessment – SciPinion Expert Panel Validates Current 1,3-Butadiene Risk Assessment Approaches
1,3-Butadiene (BD) is an important industrial chemical used as a building block precursor for synthetic rubber materials including tires, hoses, gaskets, and other polymer products. While BD serves critical industrial functions, questions have persisted about potential human health risks from environmental and occupational exposures, particularly regarding cancer and noncancer effects. Read more here.
Cancer Classification – Pesticide
A pesticide (1,3-Dichloropropene – 1,3-D) had been historically classified as a likely human carcinogen. The registrant, through a series of studies, had determined that the carcinogenic potential of the formulation was due to the carrier and not the active agent. SciPinion assembled a panel of experts in toxicokinetics, genotoxicity, cancer bioassays and cancer weight of evidence to review the literature and weigh in on how 1,3-D should be classified. The panel of experts were in agreement that 1,3-D should be classified as ‘Not Likely to be Carcinogenic to Humans’. US EPA agreed with this assessment and changed their classification of 1,3-D. Read more here.
Risk Assessment – SciPinion Panel Derived No-Significant-Risk Levels (NSRLs)
Work from a recent SciPinion panel was recently published in a manuscript entitled “Derivation of no significant risk levels for three lower acrylates: Conclusions and recommendations from an expert panel”. Novel to this approach were: (1) derivation of a panel-driven NSRL value; (2) use of nonneoplastic tumor precursor data; and (3) nonlinear extrapolation to low doses (uncertainty factor approach) based upon mode of action considerations. Read more here.
Mode of Action – Cancer Weight of Evidence Assessment for Lower Acrylates
SciPinion engaged an international panel of experts to assess the cancer weight of evidence for three lower acrylates. The review followed a three-round, modified Delphi format — a systematic process for collecting independent and deliberative input from panel members — and incorporated procedural elements designed to reduce bias and groupthink. Based on the available science, the panel concluded that the mode of action for point-of-contact tumors observed in rodent cancer bioassays involves increased cell replication driven by cytotoxicity and regenerative proliferation, and that the weight of evidence supports a cancer classification of “Not likely to be carcinogenic to humans.” Read more here.
Reproductive / Developmental Toxicant Classification
On behalf of numerous clients, SciPinion has conducted expert panels to review the weight of evidence and reach consensus on the potential for chemicals to be reproductive and/or developmental toxicants. The findings have informed regulatory decisions around the world.
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