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Ping 54 Results – Proper Dose Spacing

This Ping’s Question – Posed by a US Government Scientist:

Proper dose spacing –Some groups want to test “human-relevant” exposure levels. On the other hand, there are recommendations for testing at doses that assure the compound is being absorbed and some toxicity will be observed. MTD is being criticized for possibly producing nonspecific effects, especially with relatively non-toxic compounds.

What is the latest thinking on proper dose spacing that is feasible and functional for regulatory assessments? When should additional dose levels (>3) be added and what dose spacing is recommended to capture toxicity AND human relevant exposures (or extrapolations).

Within a week we had many great responses from very qualified individuals, we then called upon the SciPinion community to vote on the responses to determine the best answer and found a clear frontrunner.

View The Accepted Answer & All Other Responses

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What is a Ping?

A Ping is generally a concise question posed by one of the following:

  • Member of the SciPinion Community to their fellow scientists
  • SciPinion client to the SciPinion Community
  • Non-profit or Government agency to the SciPinion Community

Ping’s are meant to benefit the scientific community, scientists helping fellow scientists, creating a wealth of knowledge actively being shared between colleagues. Additionally, for some Pings, SciPinion pays out a reward (or bounty) for the best answer as voted on my the community in the app.